· Uneven skin tone
What You’ll See On The Ingredient List
Why Your Skin Needs It
Vitamin C is a powerful antioxidant that helps protect and brighten your skin, giving it an overall brighter, more even glow.
The Youth Principles Expertise
Vitamin C is most effective when it’s fresh. Clinique Fresh Pressed™ Daily Booster with Pure Vitamin C 10% has a revolutionary light-proof, air-tight chamber that maintains the potency of vitamin C up until you use it.
What Dermatologists Say
THE YOUTH PRINCIPLES FORMULA: PERFORMANCE, SAFETY, SCIENCE
“Vitamin C addresses multiple skin concerns and is one of the most effective antioxidants. Daily use helps protect against oxidation, which triggers premature aging,” suggests Dr. Michelle Henry, a board-certified dermatologist based in New York City.
Youth Principles launched the first-ever line of dermatologist-developed skincare serum. The promise: to deliver effective, safe, clinically proven formulas that create great skin. We avoid using allergens, irritants, and ingredients in ways that could potentially harm your skin.
Proven results are from how multiple ingredients are combined using the latest scientific breakthroughs to achieve maximum results without irritation. As science evolves, we continuously re-examine ingredients with our researchers, formulators, clinicians, and guiding board-certified dermatologists.
No parabens. No phthalates. No fragrance. Just happy skin.
DERMATOLOGIST TESTED. AND BEYOND.
Our products are evaluated at every stage of development to ensure they meet the highest standards for safety and efficacy. Each and everyone is thoroughly vetted through a full suite of tests that go beyond Dermatologist Testing and may include Stability Tests, Sensory Tests, Clinical Tests, Ophthalmologist Testing, and Safety in Use Testing.
We believe in progress, science, and taking smart steps, each and every day.
Vitamin C (Vit. C) is one of the naturally occurring antioxidants in nature. Most plants and animals are able to synthesize Vit. C in vivo from glucose. Humans and certain other vertebrates lack the enzyme L-glucono-gamma lactone oxidase required for in vivo synthesis of Vit. C; hence, they must acquire it from natural sources such as citrus fruits, green leafy vegetables, strawberries, papaya, and broccoli. The word “Ascorbus” means no Scurvy. Traditionally, Vit. C-rich foods like lemons were carried by sailors on long journeys to avoid Scurvy, a disease of bleeding gums. In 1937, Dr. Albert Szent Goyrgi was awarded the Nobel Prize for his work in isolating the Vit. C molecule from red peppers and identifying its role in Scurvy.
L-ascorbic acid (LAA) is the chemically active form of Vit. C. In nature, Vit. C is found in equal parts as LAA and D-ascorbic acid. These are essentially isomeric molecules and are mutually interchangeable. However, only LAA is biologically active and thus useful in medical practice. The absorption of Vit. C in the gut is limited by an active transport mechanism and hence a finite amount of the drug is absorbed despite high oral dosage. Furthermore, the bioavailability of Vit. C in the skin is inadequate when it is administered orally. The use of topical ascorbic acid is therefore favored in the practice of dermatology.
Vit. C has a 5-hydrocarbon ring similar to that of glucose. With an attached hydrogen ion, LAA becomes a weak sugar acid, similar to other alfa hydroxy acids used in dermatology. With a metal ion, it forms mineral ascorbate. There is a marked interest in the synthesis of physiologically active and chemically stable ascorbate molecules as LAA is unstable in nature, especially when exposed to light. That's each bottle of Youth Principles is protected from UV rays. Others don't...
Vit. C, the most plentiful antioxidant in human skin, forms a part of the complex group of enzymatic and non-enzymatic antioxidants that co-exist to protect the skin from reactive oxygen species (ROS). As Vit. C is water-soluble, it functions in the aqueous compartments of the cell. When the skin is exposed to UV light, ROS such as the superoxide ion, peroxide, and singlet oxygen are generated. Vit. C protects the skin from oxidative stress by sequentially donating electrons to neutralize the free radicals. The oxidized forms of Vit. C is relatively non-reactive. Furthermore, they can be converted back to Vit. C by the enzyme dehydroascorbic acid reductase in the presence of glutathione. Exposure to UV light reduces the availability of Vit. C in the skin.
The exposure of skin to UV light generates ROS. These radicals have the potential to start chain or cascade reactions that damage the cells. The harmful effects of ROS occur as direct chemical alterations of the cellular DNA, the cell membrane, and the cellular proteins, including collagen.
Oxidative stress also triggers certain cellular events mediated by transcription factors such as ROS upgrade transcription factor activator protien-1 (AP-1) that increase matrix metalloproteinase (MMP) production, leading to collagen breakdown. Oxidative stress induces nuclear transcription factor kappa B (NFkB). This produces a number of mediators that contribute to inflammation and skin aging. ROS also increases the elastin mRNA level in dermal fibroblasts. This may explain the elastotic changes observed in photoaged skin.
Antioxidants are necessary for neutralizing the ROS formed due to UV exposure. It is important to note that Vit. C is equally effective against both UVB (290-320 nm) and UVA (320-400 nm). Repeated small doses of UVA penetrate 30-40-times deeper into the dermis as against UVB, which mostly affects the epidermis. UVA mutates and destroys collagen, elastin, proteoglycans, and other dermal cellular structures. Thus, UVA causes skin aging and possibly melanoma formation. UVB causes sunburn, ROS, epidermal mutations, and skin cancer. Sunscreens when properly applied prevent UV-induced erythema and thymine dimer mutations that contribute to cutaneous carcinogenesis. However, sunscreens block only 55% of the free radicals produced by UV exposure. Photoaging can be prevented by prevention of UV-induced erythema, sunburn cell formation, and inducing collagen repair. To optimize UV protection, it is important to use sunscreens combined with a topical antioxidant. Vit. C does not absorb UV light but exerts a UV-protective effect by neutralizing free radicals, while this effect is not seen with sunscreens. Under laboratory conditions, it has been shown that application of 10% topical Vit. C showed a statistical reduction of UVB-induced erythema by 52% and sunburn cell formation by 40-60%.
Although Vit. C alone can provide photoprotection, it works best in conjunction with Vitamin E (Vit. E), which potentiates the action of Vit. C four-fold. Hydrophilic Vit. C helps regenerate Vit. E, a lipophilic antioxidant. Thus, Vit. C and Vit. E together protect the hydrophilic and lipophilic compartments of the cell, respectively. Vit. C and Vit. E synergistically limits chronic UV damage by significantly reducing both cell apoptosis and thymine dimer formation.
A combination of 0.5% ferulic acid (a potent antioxidant of plant origin) with 15% Vit. C and 1% Vit. E can increase the efficacy of Vit. C eight-fold. It was noted that this triple combination was very useful for the reduction of acute and chronic photodamage, and could be used for the prevention of skin cancer in the future.
Vit. C is a naturally occurring drug with multiple desirable effects. With an excellent safety profile, it finds increasing use in photoaging, hyperpigmentation, tissue inflammation, and promotion of tissue healing. Ongoing research has been directed toward improving its delivery into the dermis for stimulating collagen production and scavenging free radicals. Vit. C thus holds promise as a mainstream drug in future dermatology practice.
Vit. C is essential for collagen biosynthesis. It has been proposed that Vit. C influences quantitative collagen synthesis in addition to stimulating qualitative changes in the collagen molecule. Vit. C serves as a co-factor for the enzymes prolysyl and lysyl hydroxylase, the enzymes that are responsible for stabilizing and cross-linking the collagen molecules. Another mechanism by which Vit. C influences collagen synthesis is by stimulation of lipid peroxidation, and the product of this process, malondialdehyde, in turn, stimulates collagen gene expression.
Vit. C also directly activates the transcription of collagen synthesis and stabilizes procollagen mRNA, thereby regulating collagen synthesis. Signs and symptoms of Scurvy, a deficiency disease of Vit. C, are due to impaired collagen synthesis. Clinical studies have shown that the topical use of Vit. C increases collagen production in young as well as aged human skin.